Buffalo Bills open as heavy road favorites over New York Jets in Week 10

The Buffalo Bills just laid waste to the Minnesota Vikings in front of a national audience for Monday Night Football , improving to 7-1 on the season. Their reward for having won a hard-fought game against the NFL’s best defense is another road game on a short week. This time, Buffalo will travel some six hours East and South to New Jersey for a battle with their AFC East rivals, the New York Jets. Entering the Week 10 matchup, FanDuel Sportsbook has the Bills as 7.5-point favorites (-7.5) over the Jets. The over/under at publishing was set at O/U 50.5. This will be the 132nd matchup between these two teams. The first game between the franchises in the 2026 NFL season pits a playoff-minded Buffalo team against a scrappy 2-7 Jets team stuck at third in the AFC East. The Bills and Jets have a long history that dates back to September 11, 1960. Buffalo leads the all-time series 73-58. The last game between Buffalo and the Jets was Week 18 of the 2025 NFL season, played on January 4, 2026. That Week 18 game last season served as the final game in the Bills’ old stadium, with Buffalo wearing their throwback ‘90s helmets. Fittingly, that game featured the same opponent the Bills played back in 1973 for the first game in then-new Rich Stadium. Buffalo won 35-8, facing little resistance despite playing a majority of the team’s backups. The Bills are 12-4 against the Jets since quarterback Josh Allen took over as Buffalo’s starting quarterback in 2018. The series has recently belonged to the Bills, with them winning the last five games, dating back to November 2023. At 4-0, Buffalo is the only undefeated road team left in the NFL this season. Think you’ve got what it takes to make a play with the Buffalo Bills in 2026? Head over to FanDuel Sportsbook now and put your luck to the test ! Bills Mafia! Download the SB Nation app today! Bring the energy of game day wherever you go and share every reaction with fellow members of the Bills Mafia. New live chat feature during the games Fewer ads Seamlessly jump between communities and conversations Faster commenting and posting experience! Download the SB Nation app on iOS or Android .